Human Imaging

Andrew D. Smith, M.D., Ph.D
Director of Human Imaging Shared Facility (HISF)
Vice Chair of Clinical Research and Associate Professor
Oncologic and Abdominal Radiologist

UAB Department of Radiology
JTN 452, 619 19th Street South
Birmingham AL 35249-6830
(205) 934-1354 (office)
(205) 934-8110 (fax)



The goal of the Human Imaging Shared Facility (HISF) is to provide standardized imaging support of human cancer studies, leading to recognition as a NCI qualified Center of Quantitative Imaging Excellence. We will provide radiology expertise for: 1) standardized protocol review, 2) state-of-the-art image acquisition, 3) standardized tumor metrics quantification and response assessment for all imaging modalities (e.g., CT, MRI, Ultrasound, PETCT and PETMR), and 4) development and implementation of new analysis tools and techniques for the UAB Comprehensive Cancer Center’s clinical and translational research studies.

Our faculty and staff will perform early evaluations of all Cancer Center protocols involving or potentially using clinical imaging services.  Through these early evaluations, we will ensure the feasibility of trial-specific imaging protocols within the radiology clinical environment, identify requested imaging services that do not follow our typical clinical practice, and determine the appropriate level of clinical imaging and radiology staff involvement.  Any non-routine trial-related activities involving clinical imaging will then be overseen by a designated radiologist and coordinated by our dedicated research imaging coordinator, with input from a radiology research nurse coordinator and/or tumor metrics research imaging coordinator as necessary.

The specific aims are as follows:

  1. Clinical Imaging Services
  • Protocol development and assessment: evaluate all cancer research protocols involving imaging services on the UAB campus.
  • Coordinate the Cancer Center’s research activities involving imaging services, including the completion of any oncologic study specific forms or scheduling issues.
  • Provide the expertise of a designated board-certified radiologist or medical physicist, as required, for any protocol-specific non-routine imaging for cancer patients.
  • Per Cancer Center protocol guidelines, provide de-identified copies of scans/images and other protocol-specific data for the research coordinators and investigators.
  • Per protocol guidelines, coordinate pre-study services including pre-study questionnaires, phantom scans, site initiation visits, etc. to facilitate participation in multicenter or investigator initiated cancer trials.
  • Participate in preparation of research budgets for radiology elements within the Cancer Center’s protocols.
  1. Tumor metrics
  • Identify protocols requiring tumor metrics services and specifically delineate the measurement criteria.
  • Post specific protocol and tumor metrics information to a central, secure SharePoint database for readily accessible information for the designated reader and the dedicated tumor metrics research imaging coordinator.
  • Route all scans requiring tumor metrics to a designated reader and the dedicated tumor metrics research imaging coordinator.
  • Per the specific measurement criteria within the applicable protocol, and with the aid of our Tumor Metrics Tracking and Reporting Software System and local IT support, provide a timely and accurate tumor metrics report, including an image of the tumor and longitudinal data, for Cancer Center faculty serving as PIs of clinical trials.
  1. Imaging Biomarker Development, Utilization, and Translation into Clinical Trials
  • Aid in protocol development and implementation of potential imaging biomarkers for investigator initiated cancer related studies.
  • Provide advanced image data processing required for biomarker quantification.
  • Coordinate biomarker acquisition capabilities with protocol specific requirements.
  • Per protocol guidelines, provide de-identified copies of scans/images for off-site biomarker data analysis, when specified.